A 2023–2024 field study at Agropoligon Research Institute assessed foliar/nano-fertilizers (Terrasay) and growth regulators (Centrino) on wheat using a randomized complete block design. Treatments (F0–F3 at 0–2 l/ha; GR1–GR3 at 0–1.5 l/ha) significantly affected tiller count, flowering, grain yield (peaking at 4142.9 kg/ha with GR2), and nutrient content (e.g., 28.25% wet gluten with F3 × GR2). Notable interactions (p ≤ 0.048) included F2 × GR2 and F3 × GR3, enhancing fertile tillers, spike elongation, and grain weight. Tailored nano-fertilizer and growth regulator combinations show promise for sustainable wheat production.